flavokavin A, flavokawain A
| Name | Flavokawain A | ||
| PubChem CID | 5355469 | ||
| Molecular Weight | 314.3g/mol | ||
| Synonyms |
flavokavin A, flavokawain A |
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| Formula | C₁₈H₁₈O₅ | ||
| SMILES | COC1=CC=C(C=C1)C=CC(=O)C2=C(C=C(C=C2OC)OC)O | ||
| InChI | 1S/C18H18O5/c1-21-13-7-4-12(5-8-13)6-9-15(19)18-16(20)10-14(22-2)11-17(18)23-3/h4-11,20H,1-3H3/b9-6+ | ||
| InChIKey | CGIBCVBDFUTMPT-RMKNXTFCSA-N | ||
| CAS Number | 37951-13-6 | ||
| ChEMBL ID | CHEMBL243829 | ||
| ChEBI ID | CHEBI:157725 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ChangYeGeNaXiang | ||
| Habitat | GuangDong, HaiNan, India , Vietnam | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Magnoliales
-->Family: Annonaceae
-->Genus: Goniothalamus
-->Species: Goniothalamus gardneri
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| Chineses Pinyin | KaWaHuJiao | ||
| Use Part | Root and rhizome | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Piperales
-->Family: Piperaceae
-->Genus: Piper
-->Species: Piper methysticum
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| Pair Name | Flavokawain A, Herceptin | |||
| Partner Name | Herceptin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | CDK1 | hsa983 |
| Down-regulation | Phosphorylation | CDC25C | hsa995 | |
| Up-regulation | Expression | BCL2L11 | KEGG ID N.A. | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| Down-regulation | Expression | ERBB2 | hsa2064 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Down-regulation | Expression | MYT1 | hsa4661 | |
| Down-regulation | Expression | WEE1 | hsa7465 | |
| Down-regulation | Expression | SKP2 | hsa6502 | |
| Down-regulation | Expression | ERBB2 | hsa2064 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | BIM | hsa10018 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| MDA-MB-468 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0419 | |
| Result | Our results suggest FKA as a promising and novel apoptosis inducer and G2 blocking agent that, in combination with Herceptin, enhances for the treatment of HER2-overexpressing breast cancer. | |||
